BRAIN BLOOD CIRCULATION DISORDERS AND ACTIVITY OF LEUKOCYTES

Shorena Vashadze

Abstract


Every year about 6 million people in the world have a stroke. Our purpose is to study cases of brain blood circulation disorders in order to determine functional activity of leukocytes of the peripheral blood in patients with chronic ischemia and brain infarction. To carry out the comparative analysis of indicators of functional activity of leukocytes of blood with the clinical picture of a disease and indicators of the hemostasis system.

100 persons (60 men and 40 women at the age of 18 and older) who had a stroke within 1-3 weeks were examined. Tomography (MRI) in the examination of brain of primary patients with the clinical diagnosis of a stroke has been conducted. Sharp brain blood circulation disorder was confirmed by means of MRI at 35 of 100 patients. Examination of 31 patients’ brain was conducted between 3 and 12 hours after the beginning of the disease. The comparison group was made of 30 healthy persons (30%). In a group of patients with the chronic cerebral ischemia (CCI) there is an increase in quantity of leukocytes (by 1.3 times). In a group of patients with an ischemic stroke insignificant decrease in quantity of leukocytes with activated chromatin below the control indicators is noted. Degranulation of leukocytes takes place, as well as the emission of the lysosomal enzymes into the pericellular space. This confirms the participation of cells of a lymphoid line of peripheral blood in sharp cerebral ischemia. Distinct correlation between functional activity of blood leukocytes and a clinical picture of a disease and hemostasis system indicators was revealed. This can serve as a method of differential diagnostics of patients with chronic ischemia and brain infarction, as well as an objective way of controlling the efficiency.


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References


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DOI: http://dx.doi.org/10.18007/gisap:msp.v0i7.1067

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