Olga Dilekova


At immunohistochemical research of a pancreas of newborn calves endocrine islands belong to bipolar type with absence of clear polar antagonism of cells. This is characterized by incomplete processes of sorting, migration and aggregation of cells. Islands are presented by 4 types of endocrinocytes – β-cells or the insulinocytes synthesizing insulin, α-cells or the glycagon-producing cells, δ-cells or the somatostatin-producing cells and PP-cells synthesizing pancreatic polypeptide. The main cytotype is β-endocrinocytes. Their greatest volume is not only in an island, but also in the exocrine part of a gland where they are located one by one or form cellular clusters comparable to segments of the exocrine part of a gland. This is connected with incompleteness of morphogenetic processes of a gland and the anabolic property of insulin. The equal ratio is shown by α- and δ-endocrinocytes. PP-cells are single representatives.

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